States plans for avian flu pandemic
Haiti: One nurses perspective, one worlds help...
Two more suspected bird flu cases in Phichit
Long, long article with, I believe a bias, but interesting and worth reading. I took the entire article and accompanying pictures from a website called CrimeLibrary.com. Could make one want to prep for bird flu.
July 16, 2006
Culture of Deception
If ever there was a need for clear and accurate information about the spreading and rapidly mutating avian influenza, it is now as the threat of a pandemic looms increasingly large. At a time when governments and individuals around the world are making preparations to battle a potentially life-altering disaster, there is no need for a group of bureaucratic elites to decide what information people are capable of handling.
The U.N.'s World Health Organization (WHO) has published its guidelines for the communicating of information about disease outbreaks, but these guidelines have not prevented a deliberate culture of deception from dominating the statements WHO makes to the press.
It has been suggested that WHO does not want people to panic, hence they are not candid when significant events in the evolution of a pandemic are unfolding. What is wrong with this rationale?
WHO seal
On a scale of death, destruction and disaster, Hurricane Katrina would be a minor event compared to an H5N1 influenza pandemic. Would anyone suggest today that state and local governments on the
Human-to-Human (H2H) comes out of the closet
WHO cannot guarantee that H5N1 will turn into a pandemic strain and, if it does, when it will happen, any more than people on the
A pandemic can emerge as quickly as a hurricane and engulf the entire world in a few weeks on the wings — not of migratory birds — of big metal "birds" with airline logos on their sides. One big difference is that one can evacuate from the path of a hurricane, but the pandemic will be global.
Chicken
Now that most people, at least in western countries, know that the deadly H5N1 strain of avian flu is the most likely candidate for the next pandemic, many are watching the news for any sign that a major evolutionary change in the virus has occurred. The change that people have been trained to look for by countless media reports is that the virus has adapted to humans and can be easily transmitted from person to person like the annual flu.
Earlier this year, WHO did not admit to any human-to-human transmission, despite a number of very suspicious family clusters in Asia,
Maria Cheng
That is, until
And Dr. Angus Nicoll, chief of flu activities at the
In mid-April 2006, Bernard Vallat, head of the Paris-based World Organization for Animal Health (OIE) told reporters: "
Bernard Vallat
This Indonesian official's comment was greeted with scorn, but then reports of new cases went comparatively quiet at the end of April and into the first week in May. But the events that put
Family cluster is near Medan, Indonesia |
But this time it was different: facts emerged that made it impossible for WHO to sweep things under the rug, although they did try.
WHO Saves the World: the Containment Plan
WHO kept talking about a barbeque that occurred on April 29 where all the family members ate chicken and pork, implying that they all ate the same infected meat, but then it became known that the first person to die was already sick on April 27, meaning that she had probably become infected from an unknown source some 2-5 days earlier.
Village in Indonesia
As her condition worsened, many of her relatives came into close contact with her either to nurse or comfort her. Several spent the night in her small room sitting in close proximity while she coughed violently. When she died May 4, her relatives had already been infected and started dying five days later: one on May 9, one on May 10, two on May 12 and one on May 13th. From the onset dates it was likely that she had infected her family members, one of whom was still alive in the hospital.
By that time WHO's laboratory in
Tamiflu capsules
But, late or not, the WHO team would go into the village, treat everyone with Tamiflu, test the chickens and kill them if they were infected. Everything would be okay.
But it was a long way from okay.
"Evil Spirits"
The WHO team got a nasty shock in mid-May when they tried to work their usual magic on the villagers in
Testing birds in Indonesia (AP)
The villagers understood perfectly the tragedy that had befallen their neighbors: "it had been caused by evil spirits." The family had been cursed. No one would go anywhere near their three modest homes. The remaining family members had fled the village to get away from the "evil spirits" and the suspicions of their neighbors.
Declan
"...villagers concerned that their animals would be killed became hostile to outsiders, resulting in international experts and local teams being subsequently barred from the village for a whole five days. Victims refused to take Tamiflu, fled the government hospital, while families refused protective gear when caring for their sick...the list of unanticipated confusion goes on."
The villagers did not permit the WHO team to go in and test their animals so the source of the infection of the first victim will never be known. It could have been poultry, pigs, cats or any other H5N1-susceptible animal.
As if to underscore the magnitude of the
None of the villagers' behavior is necessarily WHO's fault, but it shows that the WHO containment plan won't work in much of the
On that same day, Gina Samaan, a field epidemiologist for the World Health Organization in Kubu Sembilang investigating the recent cluster told reporters that the "avian flu deaths confirmed this week on
Buying chickens in Jakarta (AP)
The Double Skip
Then on May 22 came the news that another cluster family member, Dowes Ginting, the father of 10-year-old Rafael who died of H5N1 on May 13, died right after they had brought him to the hospital. Dowes started coughing a couple of days after his son's death. He had close contact with his son, caring for him as he was dying.
Dowes was deeply depressed by his son's death, refused treatment for the deadly flu and escaped from the hospital, traveling through at least four villages before he found someone to take care of him. He sought out a local healer — referred to in the press as a "witch doctor " — and hid out in one of the local villages until he was near death, when his wife took him to the hospital.
This event created some very serious credibility problems for WHO. The infection onset dates strongly suggested that son Rafael had been infected by his aunt, the first victim in the family, and that Dowes was infected by his son. Not only did this cluster point to human-to-human transmission, it pointed to human-to-human-to-human transmission. Even worse, you have a man infected with a potential pandemic strain of the virus running around exposing any number of people. So much for the containment plan.
Did the WHO team know about Dowes? If they did know about it, why did they suppress that information and what is one to make of WHO field epidemiologist Gina Samaan's statement?
Damage Control
Something very frightening had happened in that North Sumatran village which was clearly different from other outbreaks. Not only was the variation of the virus a threat, the dangerous, but understandable, behavior of the terrified villagers compounded the threat. For the first time a huge global audience saw how a pandemic could emerge.
"All confirmed cases in the cluster can be directly linked to close and prolonged exposure to a patient during a phase of severe illness. Although human-to-human transmission cannot be ruled out, the search for a possible alternative source of exposure is continuing."
Johannes Ginting, the only survivor of the cluster family
The exposure of the family members, at least from what was described in the Indonesian press, was probably not much different than one would get sitting next to a person for a couple of hours on an airplane or children playing in school. The first victim's family members sat in a room with her for several hours, which is similar to exposure that exists in homes, schools and businesses everywhere.
"....Priority is now being given to the search for additional cases of influenza-like illness in other family members, close contacts, and the general community. To date, the investigation has found no evidence of spread within the general community and no evidence that efficient human-to-human transmission has occurred."
From now on there is no talk of "no confirmed cases of human-to-human transmission" in what WHO tells the media. Now the wording has changed ever so slightly to "no evidence that efficient human-to-human transmission has occurred." Good thing that there wasn't because that is a pandemic, but WHO never explained that to reporters.
"Full genetic sequencing of two viruses isolated from cases in this cluster has been completed by WHO H5 reference laboratories in Hong Kong and the
"The human viruses from this cluster are genetically similar to viruses isolated from poultry in
The world was left to puzzle out how something so dangerous could occur within the context of this statement. "No significant mutations?" Obviously something significant occurred in this variation of the virus. While the most of the media latched onto this phrase and trumpeted it in the headlines, others wondered if WHO's experts understood enough about the virus to even know what mutations were significant.
More Spin
On May 24 a very nervous global audience, astonished that the Indonesians had let the infected Dowes Ginting leave the hospital, was soothed by WHO spokesman Dick Thompson: "There are 33 people identified as close contacts," he told reporters. "We've asked them to observe home quarantine. That's something they are willing to do to protect themselves and their families." The number quickly rose to 54 people as WHO realized how many people Dowes had exposed in his escape from the hospital in Medan and there was absolutely no assurance that they had identified them all.
Dick Thompson
At the same time, Maria Cheng, another WHO spokesperson, told the New York Times the villagers were quarantined. She did not mention that the quarantine was voluntary, not enforced, and villagers went about their business as usual. Furthermore she neglected to mention that many refused to have their blood tested and refused the anti-viral Tamiflu. Not exactly an ideal quarantine — not even close to ideal. Upon questioning, she admitted that the villagers "had not been as cooperative as we'd like." Quite an understatement, given the facts.
In the next few days WHO continued to downplay the events in
That statement may have been true, but WHO would have had no way of knowing it when they announced it. They had no effective means of identifying everyone that had been exposed and no effective way of monitoring those that they knew had been exposed.
Keeping WHO honest
At least one expert wasn't impressed by WHO's attempts to play down the significance of the Indonesian cluster. Dr. Henry L. Niman, founder of Pittsburgh-based recombinomix, Inc., has been promoting a theory of viral evolution called recombination, which he calls "elegant evolution." Recombination, as Niman explains it, permits researchers to predict the genetic components of a pandemic influenza virus because changes in the viruses are predictable and permit vaccines to be prepared in advance.
His daily commentary on his web site and his explanations of virus behavior on discussion forums like Flutrackers have made him a popular figure among the growing number of people who closely watch the forward march of the deadly H5N1 virus. Several of his predictions have been unnervingly accurate. Niman also brings into high relief inaccuracies and spin in the WHO press releases.
Dr. Henry L. Niman
For example, WHO's desire to pretend, while it could, that human-to-human transmission did not occur in various cluster cases around the world, led various WHO spokespeople to claim during last winter's large Turkish cluster that the H5N1 incubation period was as long as 17 days. Niman punctured the credibility of this statement by referring his audience to a New England Journal of Medicine article indicating that most H5N1 infections had an incubation period of 2-5 days.
Niman always reminds his audience that the H5N1 virus doesn't read WHO press releases.
As long as WHO could keep a lid on the virus genetic information, Niman's theories on a particular cluster could not be proven. Imagine WHO's surprise when Niman was the first to expose WHO's deceptions about the virus mutations in the large Indonesian cluster that had not yet been made public.
Withholding The Evidence
WHO has been able to get away with many of its deceptions regarding the genetic mutations in the H5N1 virus because of its increasingly controversial practice of not making the genetic information public so that the world's scientific community can study it. Hopefully, this practice is coming to an end — one way or another.
Some interesting things happened when various influenza experts met in
It was no surprise to Niman that the mutations were much more extensive than WHO let on to the public. Apparently, the statement that WHO released was accurate, but the wording was very carefully parsed and much information had been left out.
Subsequently, Nature published a revealing article on the full mutations in the Indonesian cluster where human-to-human transmission took place at least twice. Declan
"WHO said on 23 May that there was 'no evidence of genetic reassortment with human or pig influenza viruses and no evidence of significant mutations.'
"The data obtained by Nature suggests that although the WHO statement was not incorrect, plenty more could have been said. Viruses from five of the cases had between one and four mutations each compared with the sequence shared by most of the strains. In the case of the father [Dowes Ginting] who is thought to have caught the virus from his son — a second-generation spread — there were twenty-one mutations across seven of the eight flu genes."
WHO has to abide by the constraints put on them by member states, who own the genetic information gathered within their countries. Countries may not permit the sharing of the influenza genetic data because they want to have an advantage in developing a vaccine faster if a pandemic strain emerges in their country — a vaccine which would find a ready market in the rest of the world. Some media reports have suggested that Indonesia is willing to share its information, but WHO has not yet formally requested it.
1918 influenza pandemic
In a world where it is increasingly difficult to get a large number of countries to agree on anything and where the levels of ignorance and poverty encourage a perfect breeding ground for the development of a pandemic strain of influenza, it is unreasonable to expect that WHO can always contain the outbreaks in time and that they can persuade corrupt and negligent governments to act responsibly.
What we can and should expect from WHO is the truth — as soon as they know it — not spin or information management that insults human intelligence. If the United Nations' World Health Organization cannot be trusted in the prelude to a pandemic, what good do they serve?
Jul 17, 2006 (CIDRAP News) – Indonesian health officials are reporting that a 44-year-old man who died last week tested positive for the H5N1 avian influenza virus, according to news services.
If the man's lab results are confirmed by a World Health Organization (WHO) accredited laboratory in Hong Kong, he will be Indonesia’s 42nd avian flu fatality and 54th confirmed case. Also, Indonesia will be tied with Vietnam for the highest avian flu death toll.
The man, who lived in East Jakarta, died Jul 12 after being hospitalized for 2 days with high fever, coughing, and breathing difficulties, Indonesian health official I Nyoman Kandun told The Jakarta Post. Kandun said the man had a history of contact with chickens, and the article said he was a fried-chicken vendor.
With the latest death, the case-fatality rate for avian flu in Indonesia is 78%, whereas Vietnam, with 93 cases and 42 deaths, has a fatality rate of 45%. According to the WHO tally, the overall case-fatality rate is 57% (230 cases, 132 deaths).
Kandun said Indonesia expects more human H5N1 cases because the disease continues to circulate throughout the country, with a presence in 27 of 32 provinces. He added that culling millions of chickens throughout the country would be too costly and urged Indonesians to take basic safety measures such as washing their hands after handling sick birds.
Vietnam seems to have stemmed avian flu outbreaks. The country has not reported a human fatality this year, whereas Indonesia has had several cases each month.
According to the Post report, the Indonesian government needs $980 million to finance its avian influenza programs from 2006 to 2008. The funds would go toward activities such as compensating farmers for culled chickens, purchasing vaccines, and planning for a pandemic.
A senior WHO official in Indonesia, Steven Bjorge, told the Post that worldwide concern about the avian flu situation in Indonesia is continuing and said he hoped that health and agriculture ministries would work more closely to fight the disease. He suggested that that comparisons between Indonesia and Vietnam can be misleading, because Indonesia is much larger than Vietnam. (Indonesia has the world's fourth largest population and the 16th largest area, whereas Vietnam ranks 12th and 65th in those measures.)
In other developments, yesterday at the Group of Eight summit meeting in St Petersburg, Russia, world leaders issued a joint statement supporting a Russian proposal to build "the WHO Collaborating Centre on Influenza for Eurasia and Central Asia," provided the center meets WHO and other international standards. Leaders also vowed to follow through on the commitments they made last January at the Beijing International Pledging Conference on Avian and Pandemic Influenza.
Meanwhile, Channel NewsAsia reported that Singapore will stage a large-scale test of its pandemic response plan on Jul 21 and 22. The test, called Exercise Sparrowhawk II, will involve 1,000 personnel from key government agencies and 19 locations, including transportation terminals, hospitals, clinics, and schools.
The report said masks will be given to visitors at hospitals, and the health ministry will ask the public to wear masks if they experience flu-like symptoms. Rapid-response teams are slated to institute infection control measures and manage initial cases at healthcare facilities. Hundreds of volunteers will play the role of patients, and police will practice for crowd-control situations, such as when people descend on clinics to purchase antiviral medications.
See also:
G8 summit statement on global fight against infectious diseases
http://www.en.g8russia.ru/docs/10.html
BY A.J. HOSTETLER TIMES-DISPATCH STAFF WRITER | Jul 17, 2006 |
Next month, wildlife officials will start searching for avian influenza among the millions of waterfowl and shorebirds that flock each fall to Virginia's coast, waterways and marshes,making them easier to catch. At least four other species will be tested as they arrive later from their summer breeding grounds up north.
In all, state and federal officials plan to sample some 800 waterfowl and about 800 shorebirds, mostly around the Eastern Shore, the Chesapeake Bay and rivers in eastern Virginia.
The samples will join a federal database that by the end of the year will number roughly 100,000, gathered by universities, private organizations, and state and federal agencies, including the departments of Interior and Agriculture.
"The resident mute swans are a good one to look at because they are highly susceptible," said ornithologist Dan Cristol of the College of William and Mary. "If one turns up positive, we will know that a migratory species brought it in and transferred it to a resident."
Virginia and other states are implementing wildlife-surveillance plans for avian influenza in addition to their public health preparations for any pandemic human flu.
The commonwealth's wide diversity of wetlands makes it a great autumnal getaway for birds heading south. That is one of the reasons Virginia is considered a primary sampling state, according to Bob Ellis, assistant director of the wildlife division for the Virginia Department of Game and Inland Fisheries. Ellis led development of Virginia's plan, which will extend through the fall.
The state's surveillance program was developed in accordance with a federal strategy as well as a plan expected to gain approval this week at a meeting of the Atlantic Flyway Council, which includes state and wildlife representatives from Maine to Florida. Ellis, who chairs the National Flyway Council, also represents Virginia on the Atlantic Flyway.
"This is almost the cart before the horse, but we can't wait too long for the [Atlantic] Flyway plan," Ellis said.
Since 2003, the H5N1 virus has killed more than 100 people and millions of birds worldwide, sparking fears that the virus could mutate into a pandemic influenza.
Dozens of species of wild birds as well as domestic poultry have been hit by bird flu. So far, officials know of no U.S. bird infected by the H5N1 virus, nor has anyone in the country been sickened by it.
Federal officials this summer are monitoring Alaska and the Pacific Northwest as the likeliest region for the virus' entry from Asia into the United States. In Alaska alone, the U.S. Geological Survey has 50 camps to take samples from 27 species of shorebirds and waterfowl, said Paul Slota, who oversees laboratory testing of the samples at the National Wildlife Center.
But the virus could also come via the Atlantic Flyway, which stretches from Greenland to Canada and south through Virginia to Florida and Puerto Rico. American birds summering in Greenland mix with those migrating from Africa and Europe, where avian flu already exists.
The first infected birds could show up along the East Coast as soon as late August or September, experts say.
By then, game and wildlife officials will have fanned out along eastern Virginia's waterways. In some cases they will be capturing live waterfowl but more often seeking out birds harvested by hunters along the Chesapeake Bay and inland waterways.
About a dozen officials will participate, and additionally game officials will work with the U.S. Department of Agriculture on a separate sampling program of live shorebirds.
Partly because of manpower issues, Ellis said, the Virginia waterfowl plan relies heavily on hunters to provide birds for sampling.
Swabs taken from the waterfowl birds' windpipes and rectums will be tested by the state Agriculture Department's lab in Harrisonburg. The USDA will reimburse the game agency $100 per bird for the sampling process, Ellis said. USDA spokeswoman Gail Kiern of the National Wildlife Research Center said the state lab will be reimbursed at least $11,200 for its work.
Any results that indicate an avian-flu strain of the H5 or the milder H7 type will be considered a preliminary positive result of avian flu. The H7 strain has cost Virginia's poultry farmers millions of dollars in recent outbreaks.
The game department will then notify the governor, state and federal health and wildlife officials and the public of any preliminary positive results. The suspected sample will be sent to the USDA's National Veterinary Services Laboratory in Ames, Iowa, for further testing, which can take several days.
Most plans for states in the Atlantic Flyway will resemble Virginia's. Where they differ will generally be in the specific avian species, the sample number and location, chosen to cast the best dragnet for avian flu, said Paul Peditto, director of Maryland's Wildlife and Heritage Service.
The plan for Maryland, which began testing similar species around the bay this month, is similar to Virginia's, Peditto said.
However, it relies more on live-bird capture because to avoid duplicating Virginia's efforts, Maryland is looking at other waterfowl, such as canvasback ducks that descend on the Chesapeake Bay, Ellis noted.
Cristol said that while he thinks migrating songbirds such as the blackpoll warbler or the gray-cheeked thrush also pose a risk in Virginia, "you can't test everything and waterfowl are the most likely carriers as far as we know."
"The $6 million question is, 'is 800 birds enough?'" he said. "Literally millions of birds move through [Virginia] in a season."
Federal officials estimate that they have a 95 percent chance of finding H5N1 even if it is present in as little as 1.5 percent of the sample bird population.
Wildlife veterinarian Jonathan Sleeman of Virginia's game agency said the target goal of 200 birds per species was developed using mathematical modeling based on the accuracy and sensitivity of the H5N1 test, random sampling and the increased prevalence of the disease and birds during fall migration.
Bird flu pandemiccould claim $800bln in first year alone - WHO | |||||
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STRELNA (near St. Petersburg), July 17 (RIA Novosti) - A bird flu pandemic could inflict hundreds of billions of dollars in economic losses within a year, an assistant director-general of the World Health Organization said Monday.
Margaret Chan said the virus was mutating to spread to humans and could cause global economic losses of $800 billion in the first year of the pandemic alone, according to data of the World Bank.
Chan said governments throughout the world must be persuaded to focus on bird flu and a human-to-human form because people have no immunity to the illness.
She added no country would be able to avoid a pandemic, but said most countries had already drafted special plans to fight avian influenza.
Since late 2003, about 200 people have died in the world from the H5N1 strain of the disease.
Avian Flu: Alberta Officials Begin Monitoring Birds for Virus - 07/17/2006
The Canadian province of Alberta, as part of a national survey, is monitoring wild waterfowl and shorebirds for possible avian influenza virus.
Alberta's surveillance program will focus on wild waterfowl and shorebirds found dead during migration from July to October. According to the government of Alberta, these birds may have used Arctic breeding grounds and may have come into contact with birds that migrated from Asia, where the dangerous Eurasian H5:N1 strain of virus has spread from domestic poultry.
The Alberta monitoring program will not include wild birds in urban or residential areas.
Alberta Sustainable Resource Development staff members will look for and collect dead waterfowl and shorebirds during the course of their work. Other government departments and cooperating agencies will be involved.
The provincial government is encouraging its residents to submit or report any waterfowl and shorebirds that they find dead in the province. These include ducks, geese, swans, plovers, sandpipers and phalaropes.
As swans seem particularly vulnerable to the H5:N1 virus, people in remote areas of northern and central Alberta where swans nest are urged to report or collect any swans found dead.
Dead waterfowl or shorebirds should be submitted fresh or should be frozen if they cannot be delivered to a Fish and Wildlife office within 24 hours, the Alberta government says. Rotten or dried-out carcasses cannot be tested for avian influenza, according to the government.
The Alberta government recommends the following basic precautions when handling dead wildlife:
The Alberta government has created a Web page with information on avian influenza in wild birds.
- Josh Cable
By Phoojadkarn Daily | 17 July 2006 02:11 |
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Date: Sun 16 Jul 2006
Indonesia: Suspected (42nd) Death from H5N1 Avian Influenza
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A 44-year-old Indonesian who died 4 days ago has tested positive for bird
flu, a senior Health Ministry official said on Sunday [16 Jul 2006], citing
a local test. If the diagnosis is confirmed by a laboratory sanctioned by
the World Health Organization (WHO), the East Jakarta man would be the 42nd
bird flu death in Indonesia, a sprawling archipelago where the virus has
killed millions of fowl and caused more human deaths this year [2006] than
in any other country. Confirmation would take Indonesia level with Viet Nam
as the country recording the most human fatalities from the H5N1 strain of
the avian flu virus. Viet Nam's 42nd death occurred in 2005. "Like so many
other bird flu cases, the man had contact with a dead chicken in his
neighborhood. He died on 12 Jul 2006, and we are now waiting for the
confirmation," I Nyoman Kandun, director general of communicable disease
control at the Health Ministry, told Reuters.
According to the WHO, the H5N1 strain has killed 132 people across the
globe since 2003. The global health arm has so far confirmed 41 deaths in
Indonesia, where the virus is endemic in poultry in nearly all of the
country's 33 provinces. Earlier this month [July 2006], a senior government
official said Indonesia's poultry death rate from bird flu was worsening,
possibly due to poor vaccination coverage. In 2005, [poultry] deaths for
the year as a whole were 1.2 million.
Indonesia has been criticized for doing too little to stamp out the H5N1
virus, which remains essentially an animal disease but which experts fear
could spark a pandemic if it mutates into a form easily transmissible
between humans. The government has so far shied away from mass poultry
culling, citing lack of funds and the impracticality of the move in a
country with millions of backyard fowl. Vaccination is the preferred method
to prevent the spread of bird flu among poultry.
Indonesia drew international attention in May 2006 when the virus killed 7
members of a single family in North Sumatra. Experts said there could have
been limited human-to-human transmission in the cluster case. On Thu [13
Jul 2006], the leading science journal Nature reported that multiple
mutations had been found in the H5N1 virus that killed the Sumatra family,
although scientists are unsure of their significance [see: Avian influenza,
human (95): China, Indonesia 20060713.1934].
[Byline: Achmad Sukarsono]
--
G8 backs Russia's proposal on center to control bird flu | |||||
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ST. PETERSBURG, July 16 (RIA Novosti) - Leaders of the Group of Eight leading industrialized nations gave their support to Russia's initiative to build within its territory a World Health Organization center for the fight against bird flu in Eurasia and Central Asia in a joint statement Sunday.
"We welcome the Russian proposal to establish the WHO Collaborating Centre on Influenza for Eurasia and Central Asia, subject to meeting all applicable WHO and other international standards, to enhance international capacity to counter the spread of the viruses in the region," the document on the fight against infectious diseases adopted at the G8 summit in St. Petersburg says.
In the statement, the leaders pledge "to help the global community prepare for a possible human influenza pandemic, including timely implementation of the commitments made at the January 2006 Beijing International Pledging Conference on Avian and Pandemic Influenza."